Question

Draw the coupling product of the Pd(0)-catalyzed Suzuki reaction between the following compounds. Show the stereochemistry of the product.

Answer 1

Concepts and reason

Coupling reaction: When two substrates are combined in the presence of a metal catalyst, it is referred to as coupling reaction. In these reactions, substrates are normally activated by using a base, which is useful to the insertion of a metal catalyst.

Fundamentals

Suzuki coupling reaction: Coupling reaction occurs between a boric acid derivative and the alkyl halide or aryl halide is called a Suzuki coupling reaction. In this reaction, a small amount of base is used to activate the boric acid.

The given reaction condition is drawn below:

In the above reaction, the reagent used is ${\rm{Pd}}{\left( {{\rm{PP}}{{\rm{h}}_{\rm{3}}}} \right)_{\rm{4}}}$ , which is useful for coupling reactions. The two given substrates are best adoptable for a Suzuki coupling reaction because one substrate is a boric acid derivative, while the other one is an alkenyl halide.

The given reaction condition is drawn below:

The product of the given reaction (Suzuki coupling) is drawn below in the products’ side.

Ans: