Question

Map Organic Chemistry Roberts & Company Publishers by Leaming Given the biaryl compound below, select the two reactants that would give this product via a Suzuki coupling. Drag and drop the appropriately labeled reactants into the starting box. Pd PPh heat, Na,CO, MgBr B(OH) SnBu3

Select the two tractants.

Answer 1

Concepts and reason

Coupling reaction: When two substrates are combined in the presence of a metal catalyst, it is referred to as a coupling reaction. In these reactions, substrates are normally activated by using a base which is useful for the insertion of a metal catalyst.

Fundamentals

Suzuki coupling reaction: Coupling reaction occurs between a boric acid derivative and the alkyl halide or aryl halide is called a Suzuki coupling reaction. In this reaction, a small amount of base is used to activate the boric acid.

The reactants of this reaction are organo boric acid and halide.

The given reaction condition is drawn below:

In the above reaction, the reagent used is ${\rm{Pd}}{\left( {{\rm{PP}}{{\rm{h}}_{\rm{3}}}} \right)_{\rm{4}}}$ , which is useful for coupling reactions. The two given substrates are best adoptable for a Suzuki coupling reaction because one substrate is a boric acid derivative, while the other one is an alkenyl halide.

The substrates of the given reaction (Suzuki coupling) is drawn below,

Ans:

The reactants of the given Suzuki coupling reaction is