Question

1. For the substituted cyclohexane compound given below, identify the groups that will sterically interact with the methyl group in a 1,3-diaxial fashion.

   

2. For the substituted cyclohexane compound given below, highlight the groups - by clicking on atoms - that will sterically interact with the methyl group in a 1,3-diaxial fashion.

   
   

Answer 1

Concepts and reason

Cyclohexane is more stable in its chair conformation. In chair conformation of cyclohexane, two types of groups are present at each carbon atom. They are axial and equatorial groups.

Fundamentals

In chair conformation, there is steric interaction developed between the axial groups present at one and third positions to each other. This type of interaction is called 1,3-diaxial interaction.

(1)

The groups that are sterically interact within 1,3-diaxial fashion are highlighted with blue colour.

[(1)]

(1)

[(1)]

(2)

In the give structure, methyl group is not in axial position.

[(2)]

Ans:

Thus, the groups that are sterically interact within 1,3-diaxial fashion are highlighted with blue colour.

Thus, the groups that sterically interact with in 1,3-diaxial fashion are highlighted with a blue colour.