Question

if a drug that blocks the reabsorption. of sodium is taken what will happen overall to the absorption. of water, urea

Plysiology 101 Porterville College Name Excellent clory Poor Score Writing Accuracy Urinary System Questions 1. If a drug that blocks the reabsorption of sodium is taken, what will happen overall to the reabsorption of water, urea, chloride, glucose, and amino acids in the proximal convoluted tubule? Explain how and why for chloride, for water, for urea, for glucose and for amino acids.

Answer 1

Tubular reabsorption is the process by which most of the substances from the filtrate are resabsorbed into blood stream .

Water ,amino acid, glucose are resabsorbed in the early proximal convoluted tubule ,but for the reabsorption to take place it needs sodium gradient maintenance means sodium is prevented to build up in the epithelial cells of the tubule and it is achieved by sodium /potassium ATPase.

Chloride ions are resabsorbed in the late proximal convoluted tubule. They are resabsorbed by chloride/anion exchange.

So, if a drug blocks the reabsorption of sodium then it will also block the reabsorption of water, chloride, amino acids and glucose . Hence there will be disturbance in the osmotic pressure and will effect the extracellular body fluid volume.