Preeclampsia is the disease condition in pregnancy wher there is
increased blood pressure may or may not accompanied by damage to
other organs like kidneys and liver. It usualy occurs after 20
weeks of pregnancy. Preeclampsia can lead to several complications
both to mother and fetus.
pharmacologic management in preeclampsia
Nifedipine
Mode of action
• Peripherally acting calcium antagonist.
Administration
• Use orally or sublingually.
• Give 10mg nifedipine, repeating dose after 30 minutes if
required.
• Maintenance dose is given 8 hourly, with a maximum dose of
20mg.
Adverse effects
• Sublingual use may cause a rapid profound BP drop and impair
uteroplacental perfusion if other agents are also in use.
• Use cautiously with MgSO4 (both antagonise calcium).
Labetalol
Mode of action
Combined α- and β-adrenergic blocker.
Administration
• Give 5-20mg boluses slowly IV at 10 minute intervals to a maximum
of 50mg.
• Alternatively, start IV infusion at 20 mg/hour. Double infusion
rate every 30 minutes as needed to a maximum of 160 mg/hour.
• May be given orally (dose: 100-200mg PO hourly, until BP
controlled - maintenance dose is given 12 hourly). Absorption may
be reduced in labour.
Contraindications
• Asthma and cardiac failure.
Intravenous hydralazine infusion
Mode of action
Direct acting arterial vasodilator.
Administration
• Never infuse hydralazine via the same cannula as magnesium
sulphate – preferably avoid using the same arm.
• Dilute 80mg (4 vials) of hydralazine in 500ml
of 0.9% saline or Hartmann’s solution (not in 5% glucose).
Infuse hydralazine at 2mg/hour (= 12.5ml/hour). The correct number
of drops per minute can be calculated from information on the
packets of the IV giving set.
• If you have a syringe-driver pump, use 40mg hydralazine in 40ml
and start at 2 ml/hour
(= 2mg/hour)
• If diastolic blood pressure (DBP) is still over 100, increase
rate by 1mg/hour and check BP in next 30 min (maximum of 5
mg/hour).
• If DBP is between 90-100 keep same rate and continue to monitor
BP every 30 min.
• If DBP is less then 90, reduce hydralazine infusion by
1mg/hour.
Monitoring
• Record BP results and rate of infusion on a monitoring
sheet.
Adverse effects
• Hypotension. If DBP decreases suddenly below 90mmHg stop the
infusion and administer a 250ml fluid bolus over 1 hour.
• Maternal tachycardia is often a limiting side effect of
hydralazine.
If severe BP ≥160/110 and/or symptoms of CNS irritability,
suggesting risk of progression to eclampsia (headache, blurred
vision), start magnesium sulphate (MgSO4).
nursing interventions
plan of action in preeclampsia
Initial assessment and management
Use ‘ABC’
Usually no problems in airway. Assess for breathing difficulties
like increased respiratory rate, auscultate to rule out the
presence of pulmonary edema.
Circulation:
Measure BP, pulse, oxygen saturation.
Left lateral tilt.
Perform blood analysis for Hb, platelets, clotting, blood
group.
If platelets low (<100x109/l) check liver function tests.
Insert urinary catheter, dip for protein, monitor urine output
hourly.
Record strict fluid balance and administer maintenance fluids
(Hartmann’s or 0.9% saline), initially at 1000ml per 12 hours.
There is a delicate balance between two potential complications;
renal failure exacerbated by hypovolaemia and fluid overload
causing cerebral and/or pulmonary oedema. Awareness of this balance
is crucial to successful treatment of patients with pre-eclampsia
and eclampsia.
If oliguric (urine output < 30ml/h average over 4 hours)
consider a modest fluid challenge (250ml 0.9% saline).
Look for oedema.
Disability: ask specifically about headache, blurring of vision or
fits
assess reflexes, looking for clonus and perform fundoscopy
Record vital signs on a flow sheet or critical care chart
Administer medications to prevent convulsions, to control blood pressure and other related commorbidities.
1 page paper Nursing intervention, pharmacologic intervention and plan of care for a patient with preeclampsia...
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