(10 pts) Predict the major product (including stereochemistry if important) of each of these elimination reactions....
5. (10 pts) Predict the major product (including stereochemistry if important) of each of these substitution reactions. Indicate whether Sn1 or Sn2. Сндон 15°C Br Br O CH CHEST CH,CHSH 60°C
3. Predict the product(s) for each of the E2 elimination reactions below. Identify the major product for each. a. Br heat V Br NaOCH heat 4. Predict the product(s) for each of the E1 elimination reactions below. Identify the major product for each. H2SO4 > OH heat
Short Answer Section (43 pts) – showing work helps! Substitution vs. Elimination (12 pts). Predict all major product(s) of each of the following reactions and indicate the predominant mechanistic pathways (Sn1, Sn2, E1, E2). Remember to consider rearrangements. Mechanism #1 (10 pts). Draw a stepwise mechanism to account for the following transformation. Br mechanism(s)? NaOH Cl mechanism(s)? NaOEt OTs for this reaction, circle the major product mechanism(s)? O K Cl for this reaction, circle the major product mechanism(s)? NaOCH3 H2O...
3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. 3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. (3 pts; no partial point) Mechanism Sn2 Sn1 HO HBr moy ng heo 0°C, H2O E2 E1 Mechanism Sn2 Sn1 H2SO4 E2 E1 Mechanism HBr SN2 Sn1 rt, H20 E2 E1 OH
3. For each of the reactions shown below, predict the single major product and determine which mechanism, S1, Sh2, E1, or E2, is operative. Briefly justify your choice. Be sure to indicate stereochemistry in the product if it is relevant s Ko'Bu BUOH C. conc. H2SO4 d. [1 equiv ) NaOMe Br MeOH
please explain the work 1. Predict the major organic product for each of the following elimination reactions, and indicate whether each one occurs via the E1 or the E2 mechanism. Be sure to clearly indicate the proper stereochemical relationships between groups (if appropriate), and write the word "racemic" under any compound that is formed as a racemic mixture. Br H3CY CH3 NaOCH3. CH3OH OH يلي H2SO4 ما H3c OTS KOt-Bu t-BuOH AgNO3 H20 Ph HC, NaOH H2O OH H2SO4
3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. (3 pts; no partial point) Mechanism SN2 Sn1 HO HBr 0°C, H20 E2 E1 Mechanism Sn2 Sn1 H2SO4 E2 E1 Mechanism HBr Sn2 Sn1 rt, H20 E2 E1
Write the major elimination product(s) of the following reactions. State whether E1, E2, or E1cB. Clearly show all stereochemistry. IL Write the major elimination produs Clearly show all stereochemistry the major elimination product(s) of the following reactions. State whether El, E2, or ElcB -CH.CH,Br (CH), (CH),COH (CH),c8 (CH),COH H-C- (CH),c8 (CH),COH CH.CH, (CH),c8 (CHOOH (CH),08 (CH),COH (CH), (CH3),COH (CH), 8 (CH),COH (CH,),c8 (CH),COH H,COTS YCH, (CH),08 (CH3),COH HC (CH),08 (CH3),COH (CH),8 (CH), COH
-OH 5. For the reactions below: a. (10 pts) Predict all products and circle the major product if more than product can be made. Remember to indicate correct stereochemistry of your products for full credit: NaCN CH3CH,CH OH b. (3 pts) In any of your elimination products for the reactions above label whether they are Zaitsev or Hoffman
C. Stereochemistry of elimination reaction (E2) Draw the major product for each of the following reactions CH0 Сн,он CH20 Сн,ОН