3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism.
3. Predict the major product (only one product) in each of the following reactions and indicate...
3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. (3 pts; no partial point) Mechanism SN2 Sn1 HO HBr 0°C, H20 E2 E1 Mechanism Sn2 Sn1 H2SO4 E2 E1 Mechanism HBr Sn2 Sn1 rt, H20 E2 E1
Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. Mechanism SN2 SN1 НО. HBr 0°С, НаО E2 Е1 Mechanism ОН SN2 SN1 H2SO4 Е2 Е1 Mechanism SN2 SN1 HBr D rt, H2O E2 Е1 ОН
2. Complete the transformation shown below. (6 pts; no partial point) ОН -ОН (not direct deprotonation) DOH reagent doesn't contain halogen atoms (only product) 3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. (3 pts; no partial point) Mechanism SN2 SN 1 ноу HBr 0°C, H20 E2E1 Mechanism SN2 SN1 H2SO4 E2 E1 Mechanism SN2 Sn1 HBr rt, H20 E2 E1
2. Complete the transformation shown below. (6 pts, no partial point) OH -OH (not direct deprotonation) reagent doesn't halogen atoms (only product) 3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. (3 pts; no partial point) Mechanism SN2 SN1 Homo HBr o 0°C, H2O E2 E1 Mechanism SN2 SN1 E2 E1 HBT Mechanism SNZ SNI rt, H20 E2 E1
2. Complete the transformation shown below. (6 pts; no partial point) OH OH D Он (not direct deprotonation) Он reagent doesn't contain halogen atoms (only product) 3. Predict the major product (only one product) in each of the following reactions and indicate the type of mechanism. (3 pts; no partial point) Mechanism SN2 SN1 Но HBr 0°С, Нао Е2 Е1 Mechanism Он SN2 SN1 H2SO4 A Е1 Е2 Mechanism SN2 SN1 HBr rt,H20 E2 Е1 ОН
3. Shown below are a series of reactions. Predict the major product for each of them. Remember, you will need to first decide whether the reaction occurs by an SN2, SN1, E2, or E1 before you can determine what the product will be. Label each as SN2, SN1, E2, or E1. Hint: First decide whether S2/E2 or S1/E1 is favored, and then decide whether the reaction pathway goes by a substitution or elimination reaction. SN2 / SN1 E2/E1 Na DMSO,rt...
6) Predict the major product in each of the following reactions and indicate if it came from an Sn1, S2, E1, or E2 reaction. H3C Br NaOme CH3 H2O H Br MeOH 'BUOK H Br DMSO H3C Br NaOme CH3 H20 MeOH H OTS ЕКОН
4. Predict the products of the following reactions & indicate whether they are most likely to go through an SN2, SN1, E1, or E2 mechanism. NaCN DMSO NaOH CH3OH heat Only one product is formed in the following E2 elimination reaction. Draw an arrow-pushing mechanism for the reaction and provide the correct product structure. Include a 3-D drawing (chair conformation) displaying proper stereochemistry of the transition state to explain formation of only the major product. CH3 •Br NaOCH3 ~"'CHS
Draw the major product and label as SN2, SN1, E2, or E1 7. Draw the major products of the following reactions, and label the reaction as SN2, SN1, E2 E1. (Darkly shaded bonds are wedged) Br NaOMe NaCN H2SO4 OTs NaSH OTs H20 NaOMe Br KOtBu OH HBr HBr OH
For the following set of reactions predict the major product(s). Underneath each product, state if they are by; SN1, SN2, E1, E2. Include stereochemistry where necessary