Question

How does neutralisation of IL-6 trans-signaling affect the autoimmune disease and inflammation? What if the trans-signaling was specifically inhibited?

Answer 1

How does neutralisation of IL-6 trans sing along affect the autoimmune disease(like-arthritis) and inflammation?

IL-6 trans singling regulates immune cell function and promotes inflammation and autoimmune diseases are critically reviewed.

Serum and synovial fluid IL-6 is markedly elevated in adult and juvenil autoimmune diseases.

IL-6, in concert with IL-17, determine the fat of CD4+ lymphocytes and therefore TH17 cell determination .

iL-6 is also plays a critical role in modulating B-lymphocyte activity.

Recognisation that IL-6 trans-singaling regulates inflammation resulted in the devlopment of tocilizumab, a fully humanized monoclonal antibody that nutrilizes the biological activity of the IL-6-receptor.

Significant clinical was demonstrated as well as reduced serum IL-6 level with suppression of xrays progression of diseases in several clinical traits in which juvenile or adult.

However level of serum and synovial fluid IL-6 Cytokine protien superfamily member.

Additional studies will be required to determine in anti-IL-6 trans-singnaling inhibition stratagies with tocilizumab or recombinant soluble IL-6R reduce the level of these cytokines.

What if the trans-singnaling was specifically inhibited?

Trans-singnaling is known to be inhibited by the circulating soluble glycoprotein 130 (sgp130).

In animal and in vitro models, trans- signaling inhibition with sgp 130 antibody clearly shows a beneficial effect on inflammatory diseases and atherosclerosis.