Question

6. Partition coefficients describe how a solute is distributed between two immiscible solvents. They are used in drug design as a measure of a solute's hydrophobicity and a proxy for its membrane permeability. If morphine has a partition coeffiecent, K, of 2 in petroleum ether and water, and a water solubility of 1.0 g/17.6 mL, what is the solubility of morphine in petroleum ether?

Answer 1

Partition coefficient = K = 2 B = {conc of morphine in ether conc of morphine in walls Is =2 (Marphine] ethes (marphine Jesher 2 - (Marphine water . 109/17,6 me Cmosphine Jetbex = 2x (1.09117.6 me) Solubility of morphine sin - 2.09 117.6 me ether