(24 pts) 3. Predict the product(s) for each reaction. Indicate stereochemistry if known. If more than...
1. Predict the product (s) (or no reaction) and reagent(s). (31 pts; no partial point) 1. TsCI, pyridine OH 2. SNa b. OH NaH C. HBr 2 eq, 0 °C d. ОН H2SO4 heat CH3 HBr Он heat f. но 1. PBr3, EtzO 2. NaCN OH NaH OTs h. Он HBr 0°C CH3 H2SO4 heat Он
Provide the major organic product (including stereochemistry if appropriate) for each of the following reactions: 3. 1) NaH а) (CH)-СHCH,ОН 2) (CH),СНОСH-CH,Br b) excess HI 1) Hg(OAc),/H,O 2) NaBHĄ/HO¯ 1) NaOH 2) PҺOH d) CH,CH,Br 1) BH3/THF 2) H-0,/Но" НCIZnClz он g) MCPBA h) 1) mCPBA 2) CH3O¯ 1) mCPBA 2) CH,ОН/Н"
Predict the product(s), both major and minor, of the following reactions. Indicate stereochemistry where appropriate. КОНЕТОН OTs Ph н н а. Ph b. THF OMs NaOCH(CH3)2 с. Н НОСHCH)2
1. For each of the following reaction state the major product(s). If there is no reaction, state NR. Specify stereochemistry where appropriate. a) H-Br b) SOCI, Py OH c) 1.TsCI/Py 2. NaBr d) PBr3 e) Conc. H2SO4, Heat 制. f) 2. NaOMe 8) 1.TsCI/Py 2. t-BuOK h) H2CrO4
3. Identify (draw the structure showing stereochemistry where required) ALL of the missing reactant, reagents, or major product to complete the following transformations. а. Nal НРО, b. H2SO4 Но KMnO4 NH2 d. он Br2 CH2CI2 CHCI кон f. но" 1. excess Hg(OAc)2, H2O/THF OH 2. NaBH g- 1. еxcess BH,/ THF 2.H2O2 h.
5. (7 pts) Predict the major product(s) for the following reactions. Remember to indicate stereochemistry, when appropriate. If no reaction is expected, write NR. C12 hv а. NBS hv b HBr ROOR с.
1. Predict the major product of the reaction. Clearly indicate stereochemistry, if necessary (3 pts) Н.С. Me 1. 9-BBN-H THF 2. NaOH H2O2 Me 2. Provide reagents to achieve the shown multi-step transformations. (6 pts) H Ph OH Ph. Br Br
25 Predict the product in the following examples, showing stereochemistry when appropriate (21) #) Write a structural formula for the principal organic products) of each of the following reactions 1) Na MON 2) H,09 CH.CH -OCH гон i 1 NaCN, DMSO 2) H 3) H,O', heat -CO,H HNO H2SO4 -NO; Br FeBry -NO, CHOCI AICI COM heat cl Febry 1) KOCH, 2) H30 b) Write a structural formula for A-C -EN 1260 1) CHI CHA Mp4r, Et (0) OH WNO...
Fill in the blanks to complete the reaction. (3pts each) Br Н-С—с—н Mg CH3CHCH2CH3 1 Ether Br (CH),CО H 2 C CH-CH,ОH CH3CH20 + 3 E1OH CI 1. ВНз 2. NaOH, H02 ОН HO 5 (CH3CH2)2CuLi 6 OH Bi Br КОН 7 Нас NaCN DMSO
1. Give the major product of the following reactions, write N.R. if no reaction happens. Indicate the stereochemistry if necessary: Jone's reagent OH OH Ph~ 1. PBr3 2. NaCN, THE conc. H2S04, n D -OH ou Naci 0 °C 0°C Ph conc. HBr Он /. heat