An amino acid does not contain an ionizable side chain. What will be its net charge...
Suppose you have a peptide composed of 4 amino acids bonded together: glutamine, glycine, glutamic acid, and the novel amino acid friendsamine, which has an ionizable side group with a pKa of 5.9. At pH 7.0, this peptide has a net charge of -2. What is the charge on the protonated form of the friendsamine side group? Explain how you determined the charge on the protonated friendsamine side group
Look up the exact pKa's of the two ionizable groups for the amino acid methionine. a) fill out a table that gives the charge on each ionizable group and the overall charge on the amino acid for eacu whole pH unit from 0 to 12 b) calculate the isoelectric point of met exactly c) compare your calculated pI from (c) with your table. d) draw the structure of the amino acid at pH 0, 7.4, and 12.
how does the protein environment surrounding an amino acid chain affect its chemical properties?Consider the carboxyl group on an asparate side chain in the following environments in a protein. Rank in order these environments from the highest to the lowest proportion of carboxyl groups in the -COO- form.that is in terms of pKas. 1. an aspartate side chain on the surface of protein with no other ionizable groups nearby. 2. an aspartate side chain buried in a hydrophobic pocket on...
1. Calculate the charge on the side chain of the amino acid histidine using the Henderson-Hasselbach equation pH = pKa + log (A/HA+). Use pH =7 and a pKa = 6 and solve to 2 significant figures. 2. Cysteine proteases have unusually reactive cysteine side chains. For one of these enzymes in solution at pH 7 you are able to measure the amount of the deprotonated sulfhydryl (ie, the negatively charged species) as 40% of the total. Calculate the pKa...
The amino acid Prolinehas a pk1 of 1.99, pk2 of 10.60. The amino acid Serine has pk1 of 2.21 and a of pk2 of 9.15. If these two amino acids bind together by peptide bond creating the peptide sequence Pro-Ser . What will be the overall charge of this peptide at the physiological pH of 7?
Which of the following amino acids has a side chain with an ionizable proton and can exist in four different forms, depending on the pH of the solution? H I. Proine CO IV. Alanine CH-d-cool Η'ΦΗ NH3 N H H II. Serie HO-CH2-c-coo NH V. Glycine H-d-cooo NH HN H IIL Histidine -CH2-Ć-COOB H NH 11 С СО СО IV v Submit Request Answer
questions e-f and g.and k.
a) Use the 3 letter symbols for a 6 amino acid peptide chain containing at least one polar and at least one acidic or basic amino acid. (All at physiological pH.) Asp - Gly-Glu-Tyr- Phe- Ala OM b) Draw the primary structure with its peptide bonds, side chains, etc. in the correct order. CH3 NH - E-N -CH. - CH - C- 2-I U=0 -ch- & N-chi- CH₃ CH ₂ Coo CH н My Coo...
What is the one-letter code for the amino acid that has a side chain that contains a secondary alcohol? T K A E G Correct answer is T What is the one-letter code for the amino acid that has a methyl group as its side chain? E A T G K Correct answer is A
What is the expected total charge of the amino acid chain APS at the pH 2, 7 and 10
Question 2 1 pts Amino acids are classified by their Rgroup (side chain) carboxylic acid group peptide bond alpha carbon amine group