Question

Cyclophosphamide and thiotepa are examples of: c Od cell-cycle specific medications. supportive therapies. carcinogenic agents. biologic response modifiers. Question 21 Calculate the absolute neutrophil count for a patient presenting with the following laboratory values: white blood cell count 4,060/mm3. neutrophils 32%, bands 3%, basophils 0%, eosinophils 0%, lymphocytes 30%, and monocytes 4%. a 1,380/mm3 1,462/mm3 1,340/mm3 1,421/mm3 Od Question 22 A 60-year-old patient with diabetes is ordered paclitaxel and cisplatin. The nurse assesses the patient's increased risk for: a pulmonary thromboembolism. Chemotherapy im....pdf Search 'o e a ou

Answer 1

question 20: C

These compounds are either electrophiles themselves or generate electrophiles in vivo to produce polarised molecules with positively charged regions. these polarised molecules can then interact with electron rich regions of most cellular molecules. The cytotoxic effect of the alkalising agents appears to relate primarily to the interaction between the electrophiles and DNA.The net effect of the alkylating agents interaction with DNA is to alter the information coded in the DNA molecule. this alteration results in inhibition or inaccurate replication of DNA , which results in mutation or cell death. one implication of the mutagenic capability of alkylating agents is the possibility that they are teratogenic or carcinogenic because they interact with DNA ,RNA and protein. Hence it is said to be the examples of carcinogenic agents.

question 21 : d

Absolute neutrophil count = ( % segment +% bands) X WBC / 100

=(32 + 3) X 4060 / 100

= 35 X 4060 /100

= 1421/mm³