Question

What are micro RNA’s? How do they work? How could RNAi be used to treat a specific disease?

Answer 1

Ins--> RNA- It is Ribo-nucleic acid There are various types of RNA : m BNA, ORNA TRNA, SMRNĄ , si RNA etc. These RNAs perform ditlerent & Specific functions RNA ris Synthesized from DNA , it cannot Form DNA l'except by the action of reverse transcriptase). It cannot duplicate (except in certain visuses where it is a genomic material) Micro RNA represent a subset of Small IRNAs , plays important role in gene regulation. -It causes gene inhibition of gene expression by decreasing specific production albeit apparently via distinct mechanisms. Represent by miRNA - micro RNAs are typically 21-25 nucleotide in length & are generated by necleolytic processing of the products of distinct genes The small processed mature miRNAS typically hybridize via the formation of imperfect RNA-RNA duplex

gene by conserved RNAS ч ехруз з іріл press micro- RNAs are a family of sman mon coding evolutionary con that regulates gene express They come from small genes 1 these microRNAS They are important in regulating ge expression during translation They form hairpin loop Structure. mRNA degradation micro RNA in plants functions a they are involved in mRNA degrada In animals they are involved in translational regulation - micro RNA bind to the 3 u TR (untranslated region) of their target mRNAs & repress protein production by destabilizing the mRNA & translational silenčiny Ans 3, RNAi linterference) RNA i is a biological process in which IRNA molecules inhibit gene expression or translation by neubidizing targeted mRNA molecules. RNAi therapy is used in cancer treatment by inhibiting certain cancer promoting genes. They are used to treat cye disease called maculas degeneration :