A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction.....
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Answer:-
Given:-
molar concentration of ATP i.e [ATP] = 5.0 mM = 5.0
10-3 M
molar concentration of ADP i.e [ADP] = 0.70 mM = 0.70
10-3 M
molar concentration of HPO42- i.e
[HPO42-] = 5.0 mM = 5.0
10-3 M
free energy change of reaction (Grxn)
= ?
As we know that
gas constant (R) = 8.314 JK-1mol-1
temperature of biological cell is = 98.6 0F = 37.0 0C
So
temperature of biological cell is = 37.0 0C = 273 + 37.0 = 310.0 K
Also we know that
ATP(aq) + H2O(l)
ADP(aq) +
HPO42-(aq)
therefore
Equilibrium constant (Keq) = [ADP][HPO42-] / [ATP] [H2O]
Equilibrium constant (Keq) = 0.70
10-3
5.0
10-3 / 5.0
10-3
1 (since [H2O] = 1 )
Equilibrium constant (Keq) = 0.70
10-3
So
According to the formula
free energy change of reaction (Grxn)
= - 2.303RTlog(Keq)
free energy change of reaction (Grxn)
= - 2.303
8.314 JK-1mol-1
310.0 K log( 0.70
10-3 )
free energy change of reaction (Grxn)
= - 2.303
8.314 JK-1mol-1
310.0 K
[ log( 0.70) +( - 3log10) ]
free energy change of reaction (Grxn)
= - 5935.61 Jmol-1
[ ( -0.1549) +( - 3) ]
free energy change of reaction (Grxn)
= - 5935.61 Jmol-1
( -0.1549 - 3)
free energy change of reaction (Grxn)
= - 5935.61 Jmol-1
- 3.1549
free energy change of reaction (Grxn)
=18726.25 Jmol-1
free energy change of reaction (Grxn)
=18.73 kJ /mol (i.e the answer)
Also we know that
free energy change of reaction (Grxn)
= + ve value = which means that reaction is non spontaneous in
nature.
free energy change of reaction (Grxn)
= - ve value = which means that reaction is spontaneous in
nature.
free energy change of reaction (Grxn)
= 0 value = which means that reaction is in equilibrium.
therefore
free energy change of reaction (Grxn)
=18.73 kJ /mol which is +ve value so reaction is non spontaneous in
nature.
therefore correct option is 'No' i.e hydrolysis of ATP is not spontaneous reaction under these condition.
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A critical reaction in the production of energy to do work or
drive chemical reactions in biological systems is the hydrolysis of
adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as
described by
ATP(aq)+ H2O(l)
ADP(aq) + H2PO4(aq)
for which ΔG°rxn = –30.5 kJ/mol at 37.0 °C and pH 7.0. Calculate
the value of ΔGrxn in a biological cell in which [ATP] = 5.0 mM,
[ADP] = 0.80 mM, and [HPO42–] = 5.0 mM.
Grxn
= ___ KJ/mol
Is the hydrolysis...