Question

15. The Philadelphia chromo a. Acute myeloid leu b. Chronic lympho c. Acute lymphocyt d. Chromic mye Hosome is commonly associate cute myeloid leukemia (AML) hic lymphocytic leukemia (CLL) te lymphocytic leukemia (ALL) "omic myeloid leukemia (CML) 16. In hemopoiesis, granulocy a. lymphoid b. myeloid c. monocyte d. killer cell ocytes such as neutrophils are for neutrophils are formed from the 17. The most abunda nt plasma protein is _ a. globulin b. clotting protein c. albumin d. bile llowing is not a phase of hemostasis? 18. Which of the following is a. vascular spasm b. fibrinolysis c. platelet plug formation d. coagulation 19. is the appearance of wh 20

Answer 1

Answer 15:

Philadelphia chromosome is generally associated with CML or chronic myeloid leukemia. Hence, option (d) is correct.

Philadelphia chromosome refers to an abnormality in chromosome 22. This chromosome is short due to reciprocal translocation between chromosome 22 and chromosome 9. The parts of these chromosome swap places and result in the formation of the BCR-ABL1 gene. This fusion gene leads to the formation of tyrosine kinase signaling protein that leads to the uncontrollable division of the cell as a result of impaired signaling pathways and instability of the genome.

Answer: 16:

Granulocytes such as neutrophil, eosinophil, and basophil are formed from the myeloid stem cell by the myoblast cells. they have a bilobed nucleus and large granules that could be stained with the help of basic dyes. Hence, option (b) is correct.

Answer: 17:

The most abundant plasma protein is albumin. Hence the correct option is (c).

It binds to fatty acids, cations, water, hormones, thyroxine, and bilirubin. Its major function is to control the oncotic pressure of blood. Oncotic pressure refers to the osmotic pressure in blood vessels induced by albumin. It displaces water molecules that result in the formation of relative water molecule deficit.

Answer 18;

The correct option is (b) fibrinolysis.

The three phases of hemostasis are vascular spasm, the formation of a platelet plug, and coagulation.

Fibrinolysis refers to the breakdown of fibrin in the coagulum as a result of enzymatic activity.