Question

SISTA

Answer 1

L'A1H4 CHCH2NH₂ Naen 'n 1289, Sayson EACN Liaun cuyen cong mata THE . . e Route -I. ni N Naisten Note: [NaBH3 (N] is a mild, more selective Ho provider reagent, Route - 2 with Nabha w 11 Tsce, py OH 2) Nang PPh3> WNH Nole! mot Tscy not v Nana (S2)

H2.e-NH2 at 3C-Nu. 2 Ant Cfzei W 1-3 CM . + H3(-N-CH3 + 2 City Na In this reaction we expect to get primary amine as a product but there will be a mixture of primary, secondary tertiary and que ternary amine . 1. Because after the first alkylation, the product formed. H3C-NH2 is a good nucleophile so it becomes more reactive and participates in further alkylation. Sia cath ~ NHz + 1H NABH₃CN Mechanism XO - Henry HO

- NH by ~ Niz tla I LiArta there (b) w e the will intermediate In be is the first reaction (as imine formation but amides in (a) method gives very high Yield