Question

APPENDIX II: PRE-LAB ASSIGNMENT 1. Which chemical group present in acetaminophen is associated with hydrolysis Hydroxyl ii) Benzene Amide 2. 1. Which product of chemical degradation is likely to produce odor Acetic acid Carbon dioxide p-aminophenol epinephrine 3. 2. Acetaminophen is more likely to hydrolysis at Acidic pH (2-4) Alkaline pH (9-12) 4. Calculate the maximum amount of p-aminophenol/5 ml permitted in the acetaminophen 100 mg/5 ml. USP limit for p aminiphenol is 0.005% w/v

Answer 1

Solution:

1) iii) Amide

Acetamenophen (paracetamol) on hydrolysis produces amine and carboxylic acid. Thus, amide functional group is involved in hydrolysis.

2) iii) p -aminophenol

p-aminophenol gives coumerin like smell.

3) i) pH 2-4

Acetaminophen undergoes hydrolysis in acidic medium to produce amine and carboxylic acid more frequently.