Question

19. Which of these molecules is activated by Akt? A) Ras b) JAK-2 c) IP3 d) GLUT-4 20. When acting as a second messenger, Ca+2 often binds to which protein? A) ceruloplasmin b) calmodulin c) Akt d) JAK-2

Answer 1

Q)

A)

19.

The all molecules are activate by AKT only.

A)Ras

Ras is consitituvely activated by AKT and it significantly decresing the cholestrol deplition induces apoptosis in HT-29 , where abrogation of Akt is expressing in HCT_166 sense those cells are very sensitive to an apoptosis by cholestrol deplition.

B)JAK-2

JAK V617F mutation will only leads to an activation of JAK-2 STAT , P13K AND AKT PATHWAYS.

C) IP3

singnaling by AKT is one of the main key outcomes of an activation.

D)GLUT-4

it is only responsible for an glucose uptake in the skeletal muscles. where as the insulin induced translocation requires an PP3 KINASE activation.this is how AKT activate GLUT-4 .

20.

CALMODULIN is the one which act as an second messenger in ca⁺² . the binding protein of calcium plays an important role in physiological roles.It is founf in n eukaryotic organism

This binding of calcium can be intracellular or extracellular .In which intracellular cells contain lack of an structural EF hand domain . Where as the extracellular are classified in 6 groups.

Hence calmodulin is an multifunctional intermediate of an calcium binding protein .