Question 1
Answer: G protein coupled receptors are transmembrane receptor protein. It has seven transmembrane spaning domains. Ligands binds to the extracellular side of the cell and trasmits the signal to G protein on the cytoplasmic side. Hence, option A and D are incorrect. Various ligands such hormones, neurotransmitters nd phermones etc., binds to G protein couple receptors and transmit the signal to G protein. Water soluble hormones acts as ligands for GPCRs but not lipid solube hormones So, Option C is the incorrect answer and Option B is the correct answer.
Question 2
Answer: G Protein are membrane associated protein that is present on the cytoplasmic side of the membrane. They are either monomeric or heteroteimeric proteins. Hence, A, C, and D are incorrect. Various ligands molecules binds to G protein couple receptors and transmit the signal to G protein. Hence, G protein works in association with G protein coupled receptors. The correct answer is Option B.
Question 3
Answer: G protein is an heterotrimeric protein made of α, β, and γ subunits and are intracellular. These subunits dissociates when bound to GTP and remain associated when bound to GDP. G protein does not bound to ATP. Hence, Options A, B and D are incorrect. The α-subunit gets activated when bound to GTP and activates enzymes. So, option C is the correct answer.
Question 4
Answer: Ligands binds to G protein coupled receptor on the extracellular side and activates G protein by replacing GDP that is bound to α-subunit of G protein with GTP. Hence, option A is correct and Option B is incorrect. Binding of the GTP to α-subunit decreases its affinity to β, and γ subunits and hence, α-subunit gets diassociates from β, and γ subunits. Hence, Option C is incorrect and option D is correct. The correct answers are Options A and D.
open to look at all pictures Multiple Choice Which of the following are true of G...
Multiple Choice Which of the following is/are true O A) IP3 binds Ca channels on the endoplasmic reticulum B) IP3 moves through cytosol C) Phospholipase C produces CAMP D) Ca binds and mobilizes proteins such as PKA E) G proteins are found on the inside of cells F) Adenylyl cyclase makes AMP from ATP G) CAMP phosphorylates target enzymes
Match the following: 1. G-protein 2. Phospholipase kinase (PLC) 3. Diacylgylceral (DAG) 4. Calmodulin 5. Calcium a. Binds to calcium and activates other proteins b. Stored in the smooth ER and binds to proteins to change their conformation c. Splits PIP2 into IP3 and DAG d. Activity is regulated by GTP and GDP e. Activates protein kinase C and is a part of PIP2
Epinephrine B-Adrenergic receptor Adenylate cyclase GDP ATP Cyclic AMP ✓ Protein kinase A Protein kinase A Describe the steps by which epinephrine causes cAMP production. [Choose ] Epinephrine binds to the extracellular portion of the beta-adrenergic receptor [Choose] The binding of epinephrine causes dimerization of its receptor. Choose] On the intracellular side, this change propagates to membrane-bound heterotrimeric G proteins. This causes them to hydrolyze GTP. [Choose ] < [Choose ] The G-proteins then dissociate into their alpha and beta/gamma...
Place in the right order the sequence of biochemical events between the release of epinephrine by the adrenal glands and the breakdown of glycogen in the liver. (1) Epinephrine is released by the adrenal glands. ( ) Activated beta-adrenergic receptors cause GTP for GDP exchange in the alpha subunits of Gs G proteins ( ) The activated catalytic subunits of PKA phosphorylate the inactive phosphorylase kinase b, activating it. ( ) Epinephrine travels in the bloodstream ( ) Two cAMP...
Indicate which of the events listed below belong to which part of the signal transduction pathway.* (6 Points) Signal Reception Signal Transduction Cellular Response Signal Termination receptor activation causes Ga to release GDP and bind GTP 0 a bind GTP TE STEEL 0 activated protein kinase enters nucleus to promote transcription. of a specific gene 0 0 adenylyl cyclase produces CAMP from ATP 0 0 0 ooo 0 0 0 adrenaline binds adrenergic receptor 0 - 0 CAMP activates protein...
1. Which of the following statements is INCORRECT? a.PKA phosphorylates a protein to begin a cell response. b. IP3 stays within the membrane and activates protein kinase C. Then protein kinase C phosphorylates a protein to initiate a cell response. c.After GTP is added, the alpha sub-unit of the G-protein slides over to activate phospholipase C. d.Calcium ions can directly initiate a cell response. e.Lipophilic ligands bind to receptors in the nucleus which then attach to DNA.
8.) which of the following statements does not describe heterotrimeric g proteins involved in the adenylate cyclase signaling pathway? a. binding to adenylate cyclase triggers the hydrolysis of PIP2 b. consist of three subunits, Galpha, Gbeta, and Ggamma c. can function as a mediator to adenylate cyclase activity d. are anchored to the cytoplasmic side of the membrane e. activates adenylate cyclase by binding to its C2a subunit 9.) which of the following is not associated with the cAMP binding...
multiple choice Select the incorrect statements A) Each Gs protein activates adenylyl cyclase for as long as it is bound to it B) Adenyl cyclases convert CAMP to AMP C) Each adenylyl cyclase produces one CAMP D) 2nd messengers are inside cells
or each of the following sentences, select the best word or phrase from the list below to fill in the blanks ot all words or phrases will be used; each word or phrase should be used only once 38. (3) An extracellular signal molecule can act to change a cell's behavior by acting through cell that control intracellular signaling proteins. These intracellular proteins that bring surface signaling proteins ultimately change the activity of about cell responses. Intracellular signaling proteins can...
Question 10-12 10. During the mating process, yeast cells respond to pheromones secreted by other yeast cells. These pheromones bind GPCRs on the surface of the responding cell and lead to the activation of proteins inside the cell. When a wild-type yeast cell senses the pheromone, its physiology changes in preparation for mating: the cell stops growing until it finds a mating partner. If yeast cells do not undergo the appropriate response after sensing a pheromone, they are considered sterile....