Place in the right order the sequence of biochemical events between the release of epinephrine by...
Place in the right order the sequence of biochemical events between the release of epinephrine by the adrenal glands and the breakdown of glycogen in the liver.
(1) Epinephrine is released by the adrenal glands.
( ) Activated beta-adrenergic receptors cause GTP for GDP exchange in the alpha subunits of Gs G proteins
( ) The activated catalytic subunits of PKA phosphorylate the inactive phosphorylase kinase b, activating it.
( ) Epinephrine travels in the bloodstream
( ) Two cAMP molecules bind to each regulatory subunit of the cAMP-dependent protein kinase (protein kinase A, PKA), causing a conformational change that results in the consequent release of the activated catalytic subunits.
( ) The activated phosphorylase kinase b phosphorylates the inactive glycogen phosphorylase b into the activated glycogen phosphorylase a form.
( ) Epinephrine reaches the liver and binds to beta-adrenergic receptors on the plasma membrane of hepatocytes
( ) Activated GTP-bound Gs proteins activate adenylate cyclase, which catalyzes production of 3',5'-cyclic AMP (cAMP) from ATP
Homework Answers
(1) Epinephrine is released by the adrenal glands.
(2 ) Epinephrine travels in the bloodstream
(3 ) Epinephrine reaches the liver and binds to beta-adrenergic receptors on the plasma membrane of hepatocytes
(4 ) Activated beta-adrenergic receptors cause GTP for GDP exchange in the alpha subunits of Gs G proteins
( 5) Activated GTP-bound Gs proteins activate adenylate cyclase, which catalyzes production of 3',5'-cyclic AMP (cAMP) from ATP
( 6) Two cAMP molecules bind to each regulatory subunit of the cAMP-dependent protein kinase (protein kinase A, PKA), causing a conformational change that results in the consequent release of the activated catalytic subunits.
(7 ) The activated catalytic subunits of PKA phosphorylate the inactive phosphorylase kinase b, activating it.
( 8) The activated phosphorylase kinase b phosphorylates the inactive glycogen phosphorylase b into the activated glycogen phosphorylase a form.
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