Place in the right order the sequence of biochemical events that after the release of insulin into the bloodstream from the pancreas leads to the translocation of GLUT4 from internal vesicles to the plasma membrane of hepatocytes.
(1) Insulin is released by the beta cells of the pancreas
( ) Binding of PKB to PIP3 promotes phosphorylation of PKB by PDK1
( ) The catalytic site of the insulin receptor phosphorylates tyrosine residues of target intracellular proteins, among which the insulin receptor substrate 1 (IRS1)
( ) Insulin travels in the bloodstream
( ) The insulin receptor dimer undergoes a conformational change that promotes the autophosphorylation of the intracellular catalytic domains of the beta subunits.
( ) Activated IRS1 binds to PI-3K and activates it
( ) Insulin reaches the liver
( ) Activated PI-3K converts PIP2 to PIP3
( ) Two insulin molecules bind to each of the two extracellular alpha subunits of an insulin receptor dimer found on the plasma membrane of hepatocytes
( ) The autophosphorylation promotes the activation of the catalytic site of the insulin receptor
(11) Phosphorylated PKB promotes the translocation of the glucose transporter GLUT4 from internal vesicles to the plasma membrane
The correct sequence should be-
1. Insulin is released by the beta cells of pancreas.
2. Insulin travels in the bloodstream.
3. Insulin reaches the liver.
4.Two insulin molecules bind to each of the two extracellular alpha subunits of an insulin receptor dimer found on the plasma membrane of hepatocytes.
5.The insulin receptor dimer undergoes a conformational change that promotes the autophosphorylation of the intracellular catalytic domains of the beta subunits.
6. The autophosphorylation promotes the activation of the catalytic site of the insulin receptor.
7.The catalytic site of the insulin receptor phosphorylates tyrosine residues of target intracellular proteins, among which the insulin receptor substrate 1 (IRS1)
8. Activated IRS1 binds to PI-3K and activates it
9.Activated PI-3K converts PIP2 to PIP3
10. Binding of PKB to PIP3 promotes phosphorylation of PKB by PDK1
11. Phosphorylated PKB promotes the translocation of the glucose transporter GLUT4 from internal vesicles to the plasma membrane
Place in the right order the sequence of biochemical events that after the release of insulin...
Place in the right order the sequence of biochemical events between the release of epinephrine by the adrenal glands and the breakdown of glycogen in the liver. (1) Epinephrine is released by the adrenal glands. ( ) Activated beta-adrenergic receptors cause GTP for GDP exchange in the alpha subunits of Gs G proteins ( ) The activated catalytic subunits of PKA phosphorylate the inactive phosphorylase kinase b, activating it. ( ) Epinephrine travels in the bloodstream ( ) Two cAMP...