Question

1) The adverse effects of SNRIs include:

• increased sedation, insomnia, and nephritis.

• cardiac arrhythmias, seizures, and CNS depression.

• GI disturbances, CNS excitation, and increased blood pressure.

• renal insufficiency, mania, and convulsions.

2) Identify a difference between secondary amines and tertiary amines.

• Tertiary amines contain three amine substitutions on the nitrogen, whereas secondary amines contain two amine substitutions on the nitrogen.

• Secondary amines mainly increase brain levels of norepinephrine more than serotonin, while the tertiary amines increase brain levels of serotonin more than epinephrine.

• Tertiary amines produce more sedation than do the secondary amines.'

3)

Which of the following statements is true of phencyclidine?

• Phencyclidine dependency appears to be predominantly psychological rather than physical.

• Unlike other anesthetics, phencyclidine is not lipid soluble.

• Phencyclidine produces its psychotomimetic effects by blocking the D₂ dopamine receptors.

• Phencyclidine is widely used today as a general anesthetic in humans.

• All of the above are correct.

Answer 1

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