Question

ize had increased, but not her hand size. No other abnormali- ties were apparent. 5. Sugges est a reason for these manifestations A 6-month course of bromocriptine (Parlodel-a dopamine onist that reduces GH secretion and shrinks the tumor) was dered, which did reduce GH levels to some extent. However, medication was discontinued, headaches, nausea, hot es, and paresthesias recurred. Several months later, a course radiotherapy to the pituitary commenced and resulted in lower GH levels and symptomatic improvement. 6. How would radiotherapy reduce the symptoms? Tests a few months later indicated Ta, cortisol, and LH levels were below normal. T4 replacement therapy was commenced. C.M. was given a supply of prednisone to take in the event of illness or increased stress. 7. Why is it necessary to maintain T, levels? Why is increased cortisol required during stress? Because of continued amenorrhea (lack of menstruation) since the pituitary infarction, a course of Pergonal (gonadotro- pins) was given to induce ovulation when pregnancy was desired. A healthy male infant was delivered. Hydrocortisone replacement was taken throughout the pregnancy. 8. Explain how the pituitary infarction caused amenorrhea. A few years later, type 2 diabetes mellitus developed, con- trolled by diet. 9. How does acromegaly predispose to type 2 diabetes? No further signs of acromegaly have occurred. Thyroxine replacement continues, and hydrocortisone is available in the event of illness. Complete evaluation of endocrine function, including hydrocortisone day curve, continues on an annual basis to monitor replacement hormone requirements. 10. Explain why hormone levels require frequent monitorin

Answer 1

ANSWER

5. Manifestations after taking bromocriptine is due to side effects of this drug and

   if the side effect are severe like heart attack,stroke and seizures immediate medical

   assistance is needed.

6.Radiation therapy help to reduce the size of the tumor that result in reduction of pressure to

   adjuscent tissues and organs which help to relieve symptoms associated with that tumor.

7. Maintain T4 levels is important because it regulate metabolic processes of the body and role in

   normal heart and muscle function,brain development,maintainance of digestion and calcium level

   in bone.

* Cortisol is a primary stress hormone which help to increase the glucose level in blood stream

     so it ensure availability of glucose for normal functioning of brain in stressful situvation.

8. Pituitary infarcton result in hypogonadotropic hypogonadism in which lack of hormones

    that are normally stimulate the ovaries (GnRH) coming from pituitary gland leads to

    amenorrhea.

9.Acromegally is occur due to high level of growth hormone production and this elevated level

   of growth hormone result in increase gluconeogenesis( formation of glucose) ,impairment in

   insulin sensitivity,changes in pancreatic beta cell function and decrease uptake of glucose by

   muscles and adipose tissues leads to type two diabetic melitus.

10. Frequent monitoring of hormone level is important because,

            * Changes in the hormone level is a sign of alteration in body processes or organ damage.

            * Early correction of hormone problems eliminate risk of organ failure.

            * Hormones are act as chemical messangers of the body so maintainance of normal

              hormone level is necessary for proper functioning of the body.