Many individuals infected with hepatitis C will fail to clear the virus in the acute phase...
Many individuals infected with hepatitis C will fail to clear the virus in the acute phase of infection and progress to chronic infection. Which factors are most likely to contribute to this failure to clear hepatitis C infection? (select two answers)
MHC with high affinity for immunogenic peptides derived from hepatitis C.
Neutralizing antibodies against HCV proteins.
Cytotoxic T lymphocyte exhaustion.
A robust interferon response.
A high rate of viral mutation.
Homework Answers
Hepatitis C infection is one of major health problem in world. It has two stages : acute and chronic. If the acute stage persists for more than 6 months it becomes chronic infection. The two reasons for hepatitis C virus that prevents its clearance in acute stage are:
1. Neutralizing antibodies against HCV proteins.
The E2 glycoprotein of hepatitis C virus (HCV) mediates viral attachment and entry into target hepatocytes and elicits neutralizing antibodies in infected patients.
2. Cytotoxic T lymphocyte exhaustion
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