Question

Question 7 Not yet answered Points out of 1.0 A new drug called XOX is in clinical trials. A patient is administered ten units of XOX and the drug distributes itself in the body. The blood or vascular compartment contains 2 units which are not bound to plasma proteins, and the remainder resides outside the blood. What is the apparent volume of distribution for XOX? Select one: Flag question a. 8L b. 2L C. 10L d.0.2L e. 1L

Answer 1

F. 5L

• Volume of distribution (Vd) = Dose administered / plasma concentration
• If volume of distribution is more, it means more amount of drug is in tissue and less is in plasma. Thus higher dose has to be administered to attain same plasma concentration for drug having high Vd than those having low Vd. Chloroquine has highest Vd (1300L/kg)
• Therefore Vd = 10/2 = 5 L

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