Question

Often in target-centered drug discovery, lead compounds will go through optimization. In lead optimization, it is often possible to modify the structure of the compound to overcome deficiencies that make them poor candidates for clinical use. If a lead compound was intended to have a low Vd so that it does not distribute to many tissues within the body, which of the following properties would be undesirable for that lead compound? C High binding affinity for the molecular target High selectivity for the molecular target C High fat-solubility C Short half-life Low toxicity

Answer 1

Option C is correct as high fat solubility will increase the distribution of the drug in this case .

Hence it is undesirable