Question

Volume Of distribution and Clearance Rate

The calcium channel blocker, Nifedipine Procardia ® the passage of calcium ions into the cytoplasm of a cardiomyocyte, therefore reducing the ce of cardiac contraction. Calcium channel blockers are used in hypertension, angina, is very effective at interfering with and cardiac dysrhythmias. a) Based on the pharmacokinetic properties measured on an individual with a mass of 2.2 kg (listed below), determine the volume of distribution and clearance rate. Assume 100% bioavailability. Dose given: 25 mg Plasma concentration: 295 ug/L Half-life: 1.85 hr mass of 82.2 kg, calculate the volume of water present. Why does this value differ from the volume of distribution? b) About 70% of the mass of an individual is due to water. For an individual with a

Answer 1

a) Vd = 0.847

CL = 1.56

b)Volume of water present is 57.54 or 58.It is differ from the volume of distribution because of thatvolume of distribution corresponds to the extrapolated plasma concentration,that means the volume of distribution is directly corresponds to the amount of blood contained in the body Vblood

c) Clearnce of a drug we can sya that the elimination of drug from the body,where the drug is having 100% bioavailability and the half life is 1.85 hr

d) The peak level of Gentamycin used for the treatment of staphylococcus infection of the gut with a Vd of 0.25 L/kg and the bioavailability is 13% and the half life is 2 hours is 5mg/kg and this was the maximum daily dose

e) The dose interval was determined ro be an aminoglycoside period that is less than 0.5mg/Lof atleast 4 hours