Question

Pain relievers (P) act by binding to receptors (R) on nerve endings. P+R = [P:R] Different pain relievers have different potencies. For example, you can take a smaller dose (fewer molecules) of ibuprofen to get the same pain relief compared with a larger dose (more molecules) of aspirin. Which statement provides the best explanation for this observation? The equilibrium constant. K. is larger for binding of ibuprofen compared with aspirin. The equilibrium constant, K. is the same for both because equal amounts of pain reliever are bound and unbound at equilibrium. The equilibrium constant. K. is smaller for binding of ibuprofen compared with aspirin.

Would the equilibrium be larger, the same or smaller?

Answer 1

For same amount of Ibupropen and Aspirin, more anxount of [P:R] is produced in сах о 1hplobли, So, {ywя мли ш . . mokes, Ibuprofen makes more [P: RJ than aspirin . So equilibrium constant a fos Ibuprofen must be greater them Aspirin , because in this case forward reaction viz 1. PERT [PER] is more favoured.. tham bas Aspirin,