Question

Questions for G2: 1) Would you expect to find valine and leucine on the outside or the inside of the tertiary structure? Why? pts) 2) State whether the following statement describe primary, secondary, tertiary, or quaternary protein (15 pts) structure A. Adjacent chains of polypeptides are held together by hydrogen bonds between the O of the carbonyl group of one chain and the H of an amide bond in another chain B. In sickle-cell anemia, valine replaces glutamic acid in the B-chain C. Peptide bonds join amino acids in a polypeptide chain

Which of the following statements Explain primary, secondary, tirtially and quaternary structures of protien

Answer 1

1) Would you expect to find valine and leucine on the outside or inside of the tertiary structure?

Here the valine and leucine are hydrophobic amino acids. Along with valine and leucine, phenylalanine are found inside the globular protein.

2) State Whether the following statements explain primary, secondary, tertiary and quaternary structures of proteins

A) Adjacent chains of polypeptides are held together by hydrogen bonds between the oxygen of the carboyl group of one chain and the Hydrogen of the amide bond in another chain.

This observation will provide explanation about the Secondary Structures of the proteins. $\alpha$ helix and the $\beta$ pleated sheedts are the major routine category of the Secondary Structures of protein. These Structures are held together by Hydrogen Bonds , between the oxygen of the carbony group of one chain and the Hydrogen of the amide bond in another chain

SECONDARY PROTEIN STRUCTURE x-helix 00000000 5/c1R B-pleated Sheet 0=0*・エー工 万一日一工 沢! -0..エーZ C H H ! cle:

B) In Sickle cell anemia, valine replaces glutamic acid in the $\beta$ - Chain

  This fact describe about the Primary Structure of the Proteins. Sickle cell anemia is a genetical disease, which causes disturbance in the red blood cells. This anemia had a minor change in a polypeptide chain which comprises hemoglobin. Here Valine replaces the glutamic acid which is in the sixth amino acid of the hemoglobin $\beta$Chain.

H H O -N- c- o- threonine- Proline lys [CH2O CH2 - C-OH glutamic acid Normal hemoglobin Amino acid substitution c - o - lys proline - N threonine - H₂C-CH-CH3 sickle cell hemoglobin. valine

c)Peptide bonds joined amino acids in the polypeptide chain

Polypeptide contains one or more amino acids which are held by peptide bonds. This definite form of the amino acids is called its primary structure

PEPTIDE CHAIN ou du dT IZ cooH NH 2 'N A CH - R3 - I Peptide bonds Amino terminus Carboxy terminus