Homework Answers
Answer .d
Decreases the binding of endogenous site ( active site)
When allosteric inhibitor binds to allosteric site, it changes the shape of active site which reduces the binding to active site.
Eg. When an allosteric inhibitor binds to a hemoglobin, it changes the shape of oxygen receptor site, thus decreases the binding of endogenous ligand.
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Which answer best describes a drug which is an allosteric inhibitor? Select one: a. binds to...
What indicates that an enzyme inhibitor binds at an allosteric site?
What indicates that an enzyme inhibitor binds at an allosteric site?a.) The inhibitor has no effect on kcat.b.) The inhibitor increases kcat.c.) The inhibitor decreases kcat.
A drug known as an 'agonist' will: Select one: a. an agonist causes agony to the...
A drug known as an 'agonist' will: Select one: a. an agonist causes agony to the patient b. bind to an antagonist drug O c. bind to the receptor and mimic the endogenous ligand d. bind to the lining of the stomach before being absorbed e. all of these answers describe an agonist drug f.bind close to the receptor binding site for the endogenous ligand, and inhibit the binding of the ligand
What occurs when a drug binds to a receptor in the body? A. It alters the...
What occurs when a drug binds to a receptor in the body? A. It alters the receptor to become nonresponsive to its usual endogenous molecules. B. It gives the receptor a new function. C. It prevents the action of the receptor by altering its response to chemical mediators. D. It increases or decreases the activity of that receptor.
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Select one compound (drug or toxicant) that targets one of the three receptor types(G-protein coupled receptor pathway, A receptor tyrosine kinase pathway, An ion channel pathway ) and discuss the fol...
Select one compound (drug or toxicant) that targets one of the three receptor types(G-protein coupled receptor pathway, A receptor tyrosine kinase pathway, An ion channel pathway ) and discuss the following for the selected compound: The name of the receptor involved The type of ligand that the drug or toxicant presents: Agonist, antagonist Are there natural ligands that interact with the receptor? If so explain the interaction. Provide a brief explanation of the mechanism of the cellular response upon ligand...
The allosteric enzyme ATCase is regulated by CTP, which binds to the T-state of ATCase. CTP...
The allosteric enzyme ATCase is regulated by CTP, which binds to the T-state of ATCase. CTP is a: Select one: O A. negative regulator. B. coenzyme. C. positive regulator. D. cofactor E. competitive inhibitor.
10) An inhibitor binds to the allosteric site of an enzyme. What is most likely to...
10) An inhibitor binds to the allosteric site of an enzyme. What is most likely to happen? a. The enzyme will be denatured b. The enyme will be natured C. The products will be created faster d. The rate of reaction will be slowed down 11) Match the organelles with their functions by placing letter (a-d) by each function: a. Ribosomes Package and ship proteins b. Golgi apparatus Store digestive enzymes C. Lysosomes Build proteins with instructions from RNA d....
3. Which of the following is true for a concerted mechanism of allosteric regulation? (a) All of ...
3. Which of the following is true for a concerted mechanism of allosteric regulation? (a) All of the subunits are in either T state or R state. (b) Binding of ligand to one site can affect neighboring sites without causing all of the subunits to undergo the T to R transition (c) The regulation of ATCase cannot be explained using a concerted model. (d) Binding of CTP to the enzyme shifts the equilibrium of all subunits simultaneously to the R...
Chapter 8. Enzyme Regulation and Inhibition 1. Competitive inhibitors are always of which type? a) allosteric...
Chapter 8. Enzyme Regulation and Inhibition 1. Competitive inhibitors are always of which type? a) allosteric b) irreversible c) reversible d) suicide 2. DIFP is: a) a competitive inhibitor b) an allosteric inhibitor c) a noncompetitive inhibitor d) a suicide inhibitor 3. Competitive inhibitors: a) bind to the active site b) bind to the enzyme-substrate complex c) bind outside the active site and decrease substrate binding d) bind outside the active site and decrease rate of catalysis.
Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent...
Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (NCT) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI Species able to form that NCI Parameters affecting the NCI ions; charged species dipole-dipole any hydrogen bond strength and orientation of dipole polarizability, size: molecular weight species with permanent dipoles (C=0, etc.) H bonded to N, O, or F and a dielectric...
A drug known as an 'agonist' will: Select one: a. an agonist causes agony to the patient b. bind to an antagonist drug O c. bind to the receptor and mimic the endogenous ligand d. bind to the lining of the stomach before being absorbed e. all of these answers describe an agonist drug f.bind close to the receptor binding site for the endogenous ligand, and inhibit the binding of the ligand
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
The allosteric enzyme ATCase is regulated by CTP, which binds to the T-state of ATCase. CTP is a: Select one: O A. negative regulator. B. coenzyme. C. positive regulator. D. cofactor E. competitive inhibitor.
10) An inhibitor binds to the allosteric site of an enzyme. What is most likely to happen? a. The enzyme will be denatured b. The enyme will be natured C. The products will be created faster d. The rate of reaction will be slowed down 11) Match the organelles with their functions by placing letter (a-d) by each function: a. Ribosomes Package and ship proteins b. Golgi apparatus Store digestive enzymes C. Lysosomes Build proteins with instructions from RNA d....
3. Which of the following is true for a concerted mechanism of allosteric regulation? (a) All of the subunits are in either T state or R state. (b) Binding of ligand to one site can affect neighboring sites without causing all of the subunits to undergo the T to R transition (c) The regulation of ATCase cannot be explained using a concerted model. (d) Binding of CTP to the enzyme shifts the equilibrium of all subunits simultaneously to the R...
Chapter 8. Enzyme Regulation and Inhibition 1. Competitive inhibitors are always of which type? a) allosteric b) irreversible c) reversible d) suicide 2. DIFP is: a) a competitive inhibitor b) an allosteric inhibitor c) a noncompetitive inhibitor d) a suicide inhibitor 3. Competitive inhibitors: a) bind to the active site b) bind to the enzyme-substrate complex c) bind outside the active site and decrease substrate binding d) bind outside the active site and decrease rate of catalysis.
Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (NCT) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI Species able to form that NCI Parameters affecting the NCI ions; charged species dipole-dipole any hydrogen bond strength and orientation of dipole polarizability, size: molecular weight species with permanent dipoles (C=0, etc.) H bonded to N, O, or F and a dielectric...
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