What are the similarities between pyrimidine synthesis and purine synthesis? What are the differences? Give an...

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What are the similarities between pyrimidine synthesis and purine synthesis? What are the differences? Give an...

What are the similarities between pyrimidine synthesis and purine synthesis? What are the differences? Give an example of a deficiency of each and how it enzymatically affects each pathway.

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Answer 1

Answer #1

SIMILARITIES	PURINE SYNTHESIS	PYRIMIDINE SYNTHESIS
1. SOURCE OF SUGAR	PRPP	PRPP
2. LOCATION	CYTOPLASM	CYTOPLASM
3. ENERGY	ENERGY REQUIRED	ENERGY REQUIRED
DIFFERENCES
1.BIOSYNTHESIS	SYNTHESIZED ON PRPP	SYNTHESIZED AND THEN ADDED TO PRPP
2.REGULATION	REGULATED BY GTP/ATP	REGULATED BY UTP
3.PRODUCTION	GENERATES IMP	GENERATES UMP/CMP
4. PRODUCTS OF DEGRADATION	URIC ACID	AMMONIA, CARBON DIOXIDE

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Answer 2

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