Question

BIOCHEMISTRY

PALA (shown below) binds to the active site of ATCase and is an important probe molecule to study ATCase regulation. PALA acts as _______________ type of inhibitor and acts to stabilize the __________-state of the enzyme.

PALA{N-(phosphonasetyl)-L-aspartate.

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A) uncompetitive/T

B) competitive/T

C) Uncompetitive/R

D) Competitive/R

E) Noncompetitive/R

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Answer #1

Answer is D).

PALA act as potent competitive inhibitor and stabilize the R state and bind to the intermediate.

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