Question

3. Match the following teratogen (drug) with the clinical disease the drug is a recommended treatment for: Drug Disease thalidomide a) ringworm b) leprosy c) acne d) tuberculosis e) malaria acutane griseofulvin 4. Polydactyly is produced by the following mechanism: a) b) c) d) e) excessive cell death failure of cell interaction reduced biosynthesis impaired morphogenic movement altered differentiation schedule

Answer 1

Drug Disease

thalidomide leprosy   

acutane acne

griseofulvin   ringworm

a). Excessive cell death

Reason:- Augmenttaion of apoptosis by cyclophosphamide resulting in excessive pograamed cell death in additional gene.