Question

Patients with heart failure, diabetes, cancer, and lung disease who have various infections from gram negative organisms often receive aminoglycosides. One of the side effects of aminoglycosides is nephrotoxicity (possible damage to the kidney). A study was performed comparing the nephrotoxicity (rise in serum creatinine of at least 0.5 mg/dL) for the aminoglycoside gentamicin. The following results were obtained: Rise in serum creatinine (2 0.5) No rise in serum creatinine (< 0.5) 45 15 Gentamicin (G) No Gentamicin (G) 25T 60

Answer 1

25. Answer is c (0.85) Please refer image for calculations

26. Answer is a (0.94)
Female Ao rise in Тото. Rise in Senum No rise in Total. Rise in serum Creatinine Serum Creatine Creatinine Serum Creatine sia 286 36 7 a 17(6+) No contanser 5% | 35(d) 40 20 @ 25(d) total. 13 63 76 27 Gentamym 94 169 mm Rhemy - Romt = ² n . a faith 3 C CQ, the 7 (6ot25 Z 8 (5+35) 76 5 (8+28 20 17+17 169 Ansurer 6 - 0.94

25 Gentamycin No Gentamycin Rise in Serum Creatinine No rise in Serum Creatinine 15 a 45 b 25 c 60 od a/catb) 15/ cist45 0.25 c/ctd) 251 (25+60) - 0.29412 Answare = 10.85 an

27. False (RR is more for men) (same calculation as per question 25)