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Why are the skin and intestinal tract the major sites of graft versus host disease (GVHD)?...

Why are the skin and intestinal tract the major sites of graft versus host disease (GVHD)?

CD4 T cells in the graft that recognize foreign histocompatibility molecules become activated and produce the cytokine interferon (IFN)-γ, which helps sustain and increase graft versus host disease (GVHD). Why is this and please explain the process from antigen recognition to rejection.

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