Why are the skin and intestinal tract the major sites of graft versus host disease (GVHD)?
CD4 T cells in the graft that recognize foreign histocompatibility molecules become activated and produce the cytokine interferon (IFN)-γ, which helps sustain and increase graft versus host disease (GVHD). Why is this and please explain the process from antigen recognition to rejection.
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Why are the skin and intestinal tract the major sites of graft versus host disease (GVHD)?...
Adaptive Immunity: Second Line of Defense—Cellular Defenses The T-cell receptors and CD4 and CD8 molecules interact with major histocompatibility complex (MHC) proteins. MHC proteins are found on most cells of the body. There are two variations, or classes, of MHC proteins. MHC class I is expressed on the surface of most cells of the body such as skin cells, liver cells, and others. Should a cell become infected with a virus, viral antigens are processed in the cells and expressed...