Question

REVIEW INSIGHT H RHNOC HMTS ONA NE но он но он Lysine peptide S-adenosylmethionine Methyllysine peptide S-adenosylhomocysteine Substrate product Figure 1 Mechanism of lysine methylation catalysed by histone lysine methyltransferases. The lysine amino group of the substrate histone polypeptide engages in an SN 2 reaction with the activated co-factor S-adenosylmethionine (SAM), resulting in the formation of an N-methylated lysine and S-adenosy homocysteine (SAH).

Label:

1. nucleophile

2. Electrophile

3. Leaving group

Also, draw a reasonable, step by step arrow pushing mechanism for the overall reaction!

Answer 1

I have marked entire molecule as nucleophile and electrophile because entire molecule is said to be nucleophile or electrophile not a single atom , nucleophilic or electrophilic centers can be one atom in entire molecule and there may be more than one nucleophile or electrophile within a molecule.

cost Leaving group. RHNOC NH > Product. Nucleophile electrophile Mechanism :- Step! CO₂H RANOC HCV SNR & NH. A 04 0! HO Cost RANOC Product RHNOC Step 2: Deprotonation: RANOG NH NH O (Product)

Thanks