Here leaving group is CH3+ , which is taken by nucleophile -NH2 group .
ming 3) The mechanism shown in figure 1 is vague (the paper was apparently not written...
Label: -nucleophile -electrophile -leaving group Draw a reasonable, step by step arrow pushing mechanism for the overall reaction. You may abbreviate non-involved parts of any of the molecules with 'R' groups, and you can assume that water is present in the reaction (to act as either an acid or a base). REVIEW INSIGHT Hмт RHNOC ON NH NO но он но он Lysine peptide S-adenosylmethionine Methyllysine peptide S-adenosy homocysteine substrate product Figure 1 Mechanism of lysine methylation catalysed by histone...
Label: 1. nucleophile 2. Electrophile 3. Leaving group Also, draw a reasonable, step by step arrow pushing mechanism for the overall reaction! REVIEW INSIGHT H RHNOC HMTS ONA NE но он но он Lysine peptide S-adenosylmethionine Methyllysine peptide S-adenosylhomocysteine Substrate product Figure 1 Mechanism of lysine methylation catalysed by histone lysine methyltransferases. The lysine amino group of the substrate histone polypeptide engages in an SN 2 reaction with the activated co-factor S-adenosylmethionine (SAM), resulting in the formation of an N-methylated...
1. Preparation of 2-chloro-2-methylbutane from 2-methyl-2-butanol involves Sw1 reaction mechanism. What does Sw1 mean? (1 pts) 2. This reaction prefers to undergo via Sw1 mechanism over Sw2. Why? (3 pts) 3. Write the structure of carbocation and nucleophile involved in this reaction. (2 pts) 4. Substrate alcohol (2-methyl-2-butanol) consists a poor leaving group (OH group). How do you covert this poor leaving group into good leaving group? (2 pts) 5. Which will be the bottom layer between aqueous and organic...