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part 1


5. If the activation energy for degradation by decreases to 12 kcal/mol under basic conditions from 18 kcal/mol at neutral pH

part 2


6. A liquid preparation of aspirin needs to be filled at a concentration of 325 mg/5 mL. The solubility of aspirin is 0.33% (

part 3

b.) In pseudo zero-order (or apparent zero-order kinetics), the formulation provides for an effectively constant concentrat

part 4

7. A compounded drug suspension has a shelf life of 21 days when stored at 5 C. Your patient notes that she left the containe
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Answer #1

Question 5.

According to the Arrhenius equation:

ln(k2/k1) = (Ea1 - Ea2)/RT

i.e. ln(k2/k1) = (18-12) kcal/mol * 1/{(2*10-3 kcal/mol.K) * (4+273) K}

i.e. ln(k2/k1) = 10.83

Therefore, k2/k1 = 50530 = 5.05*104

The units of shelf-life is sec-1, and the shelf-life increaes by 5.05*104 times.

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