Question

Write only for ONE of them.

Find information on: 1. cocaine 2. naproxen 3. levofloxacin 4. nicotine To get full credit (4 pts) you must for each: 1. Give molecular formula, structure, and IUPAC name 2. Describe biological/materials-based significance. 3. Proposed one synthetic route that would lead to a functional group or portion of the molecule. 4. Label acidic or basic functional groups and include their pKa/pKb.

Answer 1

Hi i have chosen Nicotine

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1)

Molecular formula: C₁₀H₁₄N₂

structure:

H CH3 N

IUPAC name: 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine

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2)

Nicotine is the primary alkaloid in tobacco and acts as a receptor agonist. It binds to nicotinic acetylcholine receptors (nAChRs) in brain and stimulates central nervous system (CNS) through the release of several neuro-transmitters like dopamine, nor-epinephrine, and serotonin etc. This results in elicits its psychoactive effects (Hallucinations may be!).

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3)

СOOR NaOH N 'N° N CHн- HСI / Zn / NaОН Hас НIT NaOH "ОН N HN CHз 'N CHз

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4) Nicotine is basic amine compound, due to the participation of lone pair of electron on nitrogen atom in aromatic ring, that "N" atom is slightly basic than other one.

H pKb1 6.16 CH3 pKb2 10.96

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Hope this helped you!

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