Question

1. Suppose you started with 25.8 g of salicylic acid and an excess of acetic anhydride was used to synthesize aspirin. If you obtained 21.7 g of aspirin, calculate the yield of this reaction.

(Show your detailed calculations) (1.5 Points)

3. After carrying out the aspirin synthesis experiment, suggest two experiments or techniques (give only name of Experiment) based on what you have learned last few weeks to confirm the preparation and purity of aspirin. (1 Point)

4. A commercial aspirin tablet contains 325 mg of aspirin. How many tablets could you manufacture from your aspirin? (1 Point)
5. Do you think your aspirin is suitable for preparing aspirin tablet? Why? (1 Point

Answer 1

OH cu LOH ECOH H Cho CCHg tot Balicylic Acid o=CH₂ Molar Mass = 138. 129/mol Aspirin Mass = 25.8 g Molar mass=180.16 g/mol Moles = mass - 25.8 g Molar Mass 138.12 g) mol = 0.186 mol 0. 186 mol of Salicylic Aid would produce 0. 186 mal of Aspirin. Mass of Aspirin obtained = Моол XMblos mолд I 0.186 mol X 180-16 g/mol = 33. Theoretical Yield = 33.519 Experimental yield = 21.79 percent yield & Experimental x 100 a o Theoretical 336 12 x 100 = 640 76 %

3. Thin layer chromatography and melting point measurement can be employed to confirm the preparation and purity of aspirin. Spectrophotometry can also be used.

4.

4. Mass of Aspirin through experiment = 2107 g 325 mg is present in one tablet. 21.7 g = 21700 mg is present in → 21700 mg - 66.76 tablets 325 mg [ig = 1000 mg

5. The produced aspirin may contain unreacted salicylic acid or traces of acetic acid. Hence unsuitable for preparing aspirin tablet.