Homework Answers
the phenyl-magnesium bromide
formed by bromination of phenol reacts with CO2 to form
a benzoate acid, which on further hydrolysis gives benzoic acid.
The by-product is cl-mgbr.
precautions to be taken-
1.Diethyl ether is extremely flammable and injurious. so there should not be any flame or sparkling in the lab during experimentation.
2.Bromobenzene is a skin irritant , so wear proper gloves, lab coat and avoid inhaling of fumes of bromobenzene, it may cause some breathing problems.
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Experiment 2: Grignard synthesis of benzoic acid . Complete reaction, and provide the reaction mechanism for...
1. The synthesis of Grignard reagent is challenging. a) Draw the product that is expected to...
1. The synthesis of Grignard reagent is challenging. a) Draw the product that is expected to be formed if the Grignard reagent was in contact with water prior to the reaction with MgBr CO2? (2 pts) b) Circle the correct answer. In the reaction in 1 a), phenyl magnesium bromide acts as a (nucleophile/electrophile/base/acid). (1 pt) Consider the following reaction and circle the correct answer. In this reaction, phenyl magnesium bromide acts as a, Oo MgBr MgBr (nucleophile/electrophile/base/acid). (1 pt)...
The picture below is an example of how this assignment should be done. This experiment involves...
The picture below is an example of how this assignment should be
done.
This experiment involves the synthesis of a target molecule using Grignard reagents. You must do the following: 1. Perform a retrosynthetic analysis on the target molecule. The organic starting material (what you have to work backwards toward) is provided. Draw a retrosythetic scheme; use the rightwards double arrow to show functional group transformations and disconnections. Provide synthons and synthetic equivalents for every disconnection made. 2. Propose the...
Grignard Reaction 1. Draw your complete reaction, including the formation of the Grignard reagent and the...
Grignard Reaction 1. Draw your complete reaction, including the formation of the Grignard reagent and the reaction with your carbonyl compound. Below each reagent, write its molecular weight and density (if a liquid). Also write how much of each material you will use in ml (if liquid), grams, and moles. Also include the molecular weight and melting point of your final product. 2. How many moles of Grignard reagent are you synthesizing? What mass of water could fully react with...
Experiment 12: Synthesis of Benzoic Acid pre-lab (4 pts) 1 (2 pts) Refer to the introduction...
Experiment 12: Synthesis of Benzoic Acid pre-lab (4 pts) 1 (2 pts) Refer to the introduction on the general process of hydrolysis of nitriles to carboxylic acids. Starting with benzonitrile (shown below), show how it is converted to benzoic acid under basic conditions. N 2) (2 pts) The reaction for the synthesis of benzoic acid via benzonitrile hydrolysis is shown below: 1) NaOH, HO YOH + NaCl 2) HCI, H,0 Benzonitrile Density = 1.0 g/mL MM = 103.04 g/mol Benzoic...
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepa...
i need help with the prelab questions please
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepare a Grignard reagent, phenyl magnesium bromide, from bromobenzene and magnesium metal. The Grignard reagent will then react with methyl benzoate to form triphenylmethanol. Introduction Grignard reagents, such as organomagnesium halides, were discovered in 1910 by French chemist Victor Grignard. The Grignard reaction is one of the most general methods for carbon- carbon bond formation in all of organic chemistry....
2. Predict the product and draw the mechanism for the Grignard reaction shown in the video....
2. Predict the product and draw the mechanism for the Grignard reaction shown in the video. Show all electron pairs that participate in the reaction, electron flow arrows, and intermediates. Write a paragraph describing what is happening during the mechanism. MgBr Ph H 2.NH.Cl(aq) 3. Why must this reaction be done in two steps? (In other words, what would happen in you mixed the carbonyl. Grignard reagent, and the aqueous ammonium chloride all together?) 4. In this reaction NHCI was...
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepa...
i need help with the postlab questions please
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepare a Grignard reagent, phenyl magnesium bromide, from bromobenzene and magnesium metal. The Grignard reagent will then react with methyl benzoate to form triphenylmethanol. Introduction Grignard reagents, such as organomagnesium halides, were discovered in 1910 by French chemist Victor Grignard. The Grignard reaction is one of the most general methods for carbon- carbon bond formation in all of organic chemistry....
Experiment: Passerini Reaction t-butyl isocyanide + benzaldehyde + benzoic acid were reacted to form 2-(tert-butylamino)-2-oxo-1-phenylethyl benzoate....
Experiment: Passerini Reaction t-butyl isocyanide + benzaldehyde + benzoic acid were reacted to form 2-(tert-butylamino)-2-oxo-1-phenylethyl benzoate. Water was used as the medium for the reaction, allowing for faster reaction times and higher yields (is an example of green chemistry technique, since no organic solvents are involved in the synthesis of the reaction itself). QUESTIONS: 1. Consider the molecular structure of the Passerini Product. In light of the composition of the compound, explain the observations you made regarding its behavior upon...
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry....
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry. You are assigned two target molecules, one of which is best synthesized by an alkylation approach, while the other is best synthesized by an addition or condensation approach. My two target molecules are number 2 and number 12 in the last page. You must do the following: 1. Perform a retrosynthetic analysis on the two target molecules assigned to you. In each case the...
Page 1 Synthesis using Carbonyl O-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules...
Page 1 Synthesis using Carbonyl O-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry. You are assigned two target molecules, one of which is best synthesized by an alkylation approach, while the other is best synthesized by an addition or condensation approach. You must do the following: 1. Perform a retrosynthetic analysis on the two target molecules assigned to you. In each case the organic starting material (what you have to work backwards toward) depends...
1. The synthesis of Grignard reagent is challenging. a) Draw the product that is expected to be formed if the Grignard reagent was in contact with water prior to the reaction with MgBr CO2? (2 pts) b) Circle the correct answer. In the reaction in 1 a), phenyl magnesium bromide acts as a (nucleophile/electrophile/base/acid). (1 pt) Consider the following reaction and circle the correct answer. In this reaction, phenyl magnesium bromide acts as a, Oo MgBr MgBr (nucleophile/electrophile/base/acid). (1 pt)...
The picture below is an example of how this assignment should be
done.
This experiment involves the synthesis of a target molecule using Grignard reagents. You must do the following: 1. Perform a retrosynthetic analysis on the target molecule. The organic starting material (what you have to work backwards toward) is provided. Draw a retrosythetic scheme; use the rightwards double arrow to show functional group transformations and disconnections. Provide synthons and synthetic equivalents for every disconnection made. 2. Propose the...
Grignard Reaction 1. Draw your complete reaction, including the formation of the Grignard reagent and the reaction with your carbonyl compound. Below each reagent, write its molecular weight and density (if a liquid). Also write how much of each material you will use in ml (if liquid), grams, and moles. Also include the molecular weight and melting point of your final product. 2. How many moles of Grignard reagent are you synthesizing? What mass of water could fully react with...
Experiment 12: Synthesis of Benzoic Acid pre-lab (4 pts) 1 (2 pts) Refer to the introduction on the general process of hydrolysis of nitriles to carboxylic acids. Starting with benzonitrile (shown below), show how it is converted to benzoic acid under basic conditions. N 2) (2 pts) The reaction for the synthesis of benzoic acid via benzonitrile hydrolysis is shown below: 1) NaOH, HO YOH + NaCl 2) HCI, H,0 Benzonitrile Density = 1.0 g/mL MM = 103.04 g/mol Benzoic...
i need help with the prelab questions please
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepare a Grignard reagent, phenyl magnesium bromide, from bromobenzene and magnesium metal. The Grignard reagent will then react with methyl benzoate to form triphenylmethanol. Introduction Grignard reagents, such as organomagnesium halides, were discovered in 1910 by French chemist Victor Grignard. The Grignard reaction is one of the most general methods for carbon- carbon bond formation in all of organic chemistry....
2. Predict the product and draw the mechanism for the Grignard reaction shown in the video. Show all electron pairs that participate in the reaction, electron flow arrows, and intermediates. Write a paragraph describing what is happening during the mechanism. MgBr Ph H 2.NH.Cl(aq) 3. Why must this reaction be done in two steps? (In other words, what would happen in you mixed the carbonyl. Grignard reagent, and the aqueous ammonium chloride all together?) 4. In this reaction NHCI was...
i need help with the postlab questions please
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepare a Grignard reagent, phenyl magnesium bromide, from bromobenzene and magnesium metal. The Grignard reagent will then react with methyl benzoate to form triphenylmethanol. Introduction Grignard reagents, such as organomagnesium halides, were discovered in 1910 by French chemist Victor Grignard. The Grignard reaction is one of the most general methods for carbon- carbon bond formation in all of organic chemistry....
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry. You are assigned two target molecules, one of which is best synthesized by an alkylation approach, while the other is best synthesized by an addition or condensation approach. My two target molecules are number 2 and number 12 in the last page. You must do the following: 1. Perform a retrosynthetic analysis on the two target molecules assigned to you. In each case the...
Page 1 Synthesis using Carbonyl O-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry. You are assigned two target molecules, one of which is best synthesized by an alkylation approach, while the other is best synthesized by an addition or condensation approach. You must do the following: 1. Perform a retrosynthetic analysis on the two target molecules assigned to you. In each case the organic starting material (what you have to work backwards toward) depends...
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