Question

How does the kreb's cycle relate to the study of pathophysiology?

Answer 1

Aerobic organisms normally lives and grows in an environment rich with oxygen. Tricarboxyoxilic cycle or citric acid cycle or Krebs cycle defined as a process of chemical reactions that used by all aerobic organisms to generate energy.

Normally any alteration in Krebs cycle results in alteration in cellular respiration. For example , cancer cells inhibits normal cellular processes in energy synthesis. Cancer cells synthesis energy using glycolysis in an anaerobic environment. This in turn hinders the Krebs cycle that leads to disturbance in production of intermediates.

Thus understanding normal krebs cycle process helps to understand the disease process.