5. (a) Propose a mechanism for the reaction of 2-bromopyridine with sodium amide to give 2-...
3. Give the detailed mechanism of the following reaction and name the amide and the products: - Br КОН ethanol-water, heat OK + H2N- 4. Synthesize the following compound by using a nitrile and a Grignard reagent. You need to show the synthesis of the nitrile and Grignard reagent. 5. Propose a scheme for synthesizing the following compound using methyl cyclopentanecarboxylate, iodomethane and other reagents : -OH
8. (i) Propose a product for the following reaction below and give a mechanism for its formation: 2. K 2HN (ii) Provide a muti-step mechanism for the following reaction: 0 0 CI OCH (ii) The product morpholine is synthesised as shown. Give a mechanism for each of the steps: NHt +
4
4) Write the reaction product and use the curved arrow notation to draw a mechanism that accounts for the formation of product upon oxymercuration/ reduction of cis-4-hexenoic acid in aqueous THF. (8 points) a) Write the reaction. 1) Hg(OAC), aq, THE 2) NaBH, aq. THE HO cis-4-hextenoic acid b) Write a mechanism.
1. Provide a reasonable mechanism to account for the following
reaction.
3. Propose a reasonable mechanism for the following
reactions.
7. Propose a mechanism for the formation of the
following products.
NO2 H2SO4 HNO; Br Br AICI: + CI Br FeBrz AICI: -CI
1) Draw the mechanism for the formation of 2-bromopropane. Use the mechanism to explain why 1-bromopropane is not formed in this reaction. (10 points) HB Nol 2) Draw the mechanism for the reduction of methylethylketone by sodium borchydride (10 points) o NABH OH + HO
Reaction of ortho-bromotoluene with sodium amide in liquid ammonia produces two major products, ortho-toluidine (i.e., 2-methylaniline) and meta-toluidine (i.e., 3-methylaniline). From the list of possible intermediates shown at the right, choose those that would be: an intermediate in the formation of ortho-toluidine. an intermediate in the formation of meta-toluidine
09 Question (1 point) Draw a mechanism for the reaction of ethanol with sodium amide, In the box to the left, draw any necessary curved arrows. Show the products of t reaction in the box to the right. Include any nonzero formal charges and all lone pairs of electrons. Finally, check the box to indicate which side of th reaction is favored at equilibrium 3rd attempt M See Periodic Table Part 1 (0.7 point) n to this proton transfer reaction.
PROBLEM 5. Reaction Mechanism 1. Propose products (major/minor) and provide a detaile reaction mechanism to account for the formation of the major product. Use curved arrow notation to indicate electron flow. Also, draw a structure of the transition state that accounts for the formation of the major product HЕr он 0° C major minor transition state corresponding to the major product of 20 points
Whats the mechanism of this reaction to give
quinine
Problem 4: (10pts) Suggest a reasonable chemical mechanism synthesis of alkaloids Quinine and give a chemical structure of Compounds A, B, C, D, E according the following reaction scheme: Pr,NC H.so THF NaBH, Bu AlH Ba(OH)2 OH (-)-Quinine
Question 3 Consider the reaction shown below. CEN ОК KOH H20 Propose a detailed mechanism using curved arrows in a step by step manner to illustrate the formation of the carboxylic acid salt formed in this reaction. Make sure to use curved arrows to show the deprotonation, protonation, bonds formation or bonds cleavage.