Question

stion 17 What is the order of reactivity of the following carboxylic acid derivatives from most reactive to least reactive towards nucleoph 22 Ester Acid chloride Acid anhydride Amido Carboxylate anion [a] [b] (c) (d (e) Specified Answer for a Specified Answer for b Specified Answer for c Acid chloride Acid anhydride Carboxylate anion Ester Specified Answer for d Specified Answer for e Amide

Answer 1

The reaetvity or des toi the caboxilye acid destvetives b the Tucleophile mainly depents an the electophiliet the Casbonyl cybon Nore elechophilc toe. canbony Cayban mare hill be the geaatvity. Amd another Considetable tactor in this reaard is the steric hindhane. More Steric hindiamce anornd the earbonyl Cerben lens will be t Yeactivity as the mucleophile aAmnst attaik exter acid chloride, geid anhy dide, amide S0 omd corbenylate in the Yeaatvity ai dar in acid Acid chlonde anide Gbeny late erd ion (e) d's ester amlyhide (b) (AJ

Thin 'in dve to in Beid chloride Re due to psesenie a- el (higty eleetonegehve) the carbomyl canbtntoccame too mueh electoph1ic Tn thin acid anlydhide Reo inavery geod R RC00 R lesing poup muateophilicattauk easter. les due to teric reason n Csterr R aR reactivi Cmd prerenee a-OR Yedheen the elechophileity Carsbonyl corbon at In amide tn mere steric hhndered than etes P amd delocalivation a lone palr aN Ith Shony Phihcity at Carbonyl carban dease asen. R no, the eleeto

And in the ear boreyhe aeld mastly in caboxylate tom) Comple le delecalinationalone peir No R GE reaetivit n teast R R. shrong deloeatination deloealisation Complete Some Weak Vesy Heak deloealisation deloaalina debaalisation tion earbon Arom tett to nignt the eleatoiety deoreasen amd correspondingy eactiuity touadh the carbanyg pucleophile atso deareasen.