Question

The anticancer drug paclitaxel (Taxol), derived from the Pacific Yew, has many effects on mitosis. One of its most powerful effects is that it prevents disassembly of the mitotic spindle, which prevents spindle fibers from shortening. Which phase of mitosis would this directly affect? Why would this stop cell division overall and lead to cell death?

Answer 1

PACLITAXEL

Paclitaxel is a chemotherapeutic agent that comes under the group MITOTIC INHIBITORS- TAXANE

Mitotic inhibitors prevents mitosis, causing cell death.

Mitotic inhibitors are cell cycle phase -specific and act on the M phase, where it prevents the spindle formation.

Mechanism of action

Paclitaxel is a cytoskeletal drugs that target tubulin. Paclitaxel - treated cells have defects in mitotic spindle assembly, chromosome segregation and cell division. Paclitaxel stabilizes the microtubule polymer and protects it from disassembly. chromosomes are thus unable to achieve a metaphase spindle configuration. this blocks the progression of mitosis and prolonged activation of the mitoic checkpoint triggers apoptosis or reversion to the G0- phase of the cell cycle without cell division.

4) ANTIBIOTIC

Since the patient has severe infection and want to get an antibiotic as soon as possible for quick result it is recommended to give Azithrolyse'Em 200g/mol IV immediately after test dose. Penikill'Em is also effective during infection but it is less effective in viral infection. The patient who is taking 10 days of penicillin dose can have to take Azithromycin for only 3 doses. They come under the group macrolide antibiotic, prevents bacterial growth by interfering with their protein synthesis. it binds to the 50S subunit of the bacterial ribososme, thus inhibiting translation of mRNA.