4. Provide the products of each reaction (3pts, 2pts) 1. H2O+ OCH; 2. NaOCH, CHOH OCH 3. H, A 4. NaCN 1. LDA 2. Pho 3. H , A 4. EtMgBr 5. Provide an arrow-pushing mechanism for the reaction below, and state how many product stereoisomers are possible (5 pts) NO2 cat. KOH ЕКОН
1. LDA 1. LDA 2. CI 3, H30+ o 2. H 3.H30+
Provide the products of each reaction (3pts, 2pts) 1. HgO* 2. NaOCH3 4. OCH HORD OCH3 3. Η ' Δ 4. NaCN 1. LDA 2. Ph 3. H, A 4. EtMgBr
4. Provide the products of each reaction (3pts, 2pts) 1. H,O* OCH; 2. NaOCH, CHOH OCH, 3. H, A 4. NaCN 1. LDA 2. Pho 3. H , A 4. EtMgBr
1. predict the products KOH, H2O + Ph H heat a. (21.4) 1. LDA (strong bulky base) vi H b. 2. then heat H (21.4) c. NaOH/ H2O i i H cold (21.3) 1. LDA ܘܐ 2. e. 3. mild acid for neutralization (21.5) 2. Predict the products NaOCH2CH3 1. NaOH/H2O 2. H HOCH2CH3 Br Br 3. Heat a. Nao in ethanol of b. (C9H1403) 21.8 ol H*, Brz. C. (21.1) NaOH, Bra d. (21.3) PC13, Br2 ОН e. (21.1)
(more synthesis, continued. 2 points each) 2 Bra 2 NaOH Ph water g. 1. LDA 1. NaOCHs CHOH 2. BrCH CH2CHs 3. H', H20, heat H Ph (warmup, long time) NaOEt k. OEt EtOH 1. PPhs Br 2. BuLi 3.
O P enter return U K shift ? Aldal Codesafra Readn 4. Provide the products of each reaction (3pts, 2pts) 1. H30* 2. NaOCH3 CH OH 3. H*, A 4. NaCN OCH3 OCH3 ? 1. LDA 2. Ph ? 3. H*, A 4. EtMgBr
4. Provide the products of each reaction (3pts, 2pts) 1. HO- Осн. 2. NaOCH CH,OH ? OCH 3. H.A 4. NaCN 1. LDA 2. Pho 3. H, A 4. EtMgBr
Mechanism with major product included 1) LDA 2) ?: O: c) 3) H,o* : O 1) LDA 2) : Br d) : Ci: NaOEt E2 e)
Predict the major product of each reaction below: 1) EtMgBr 2) H20 Edit H. 1) PhMgBr 2) H20 Edit SHOW HINT 1) PhMgBr 2) H;O