Question

1. (16 points) In each of the following pairs of reactions elimination competes with substitution. Write the starting material and all possible products of the reactions, don't write mechanistic part. Write "elimination is favored for reaction in which elimination products can be obtained in higher yield comparing to the yield of the elimination product/s in the second reaction. Provide the reason for such statement, reason is in reaction conditions. You can write an opposite statement to the previous one, you can write "substitution is favored" if it is easier to reason this type of statement. a. (1) bromocyclohexane reacts with potassium methoxide at 15°C (2) bromocyclohexane reacts with potassium methoxide at 60°C b. (1) 2-chloro-2,3,3-trimethylpentane reacts with sodium hydroxide at room temperature (2) 2-chloro-2,3,3-trimethylpentane reacts with sodium tert-butoxide at room temperature NaCN 15 NaOEt aqueous H2SO4 et at aqueous H2SO NaBr

Answer 1

© B dhe of81@ minor) ( 20 x-x+ O (mejor) algo (strong bule) L Elimination Bahko 99%. cstrong base) & high t o temperature a) Elimination favore 2° k Oi Naolt C Elimination is favored zoox ton strong base E2) ist-luomo, de t-Buono 30 R + t-Bud C strong base) E 2) 10 R x + Strong naleophile = sue No Rx+ strong nudeophile Coel ) = SN ₂ sou - Elimination major) ceq ty sou CSN) (minor)