Question

1. To which mechanism(s) if any does each statement apply? Fill in each blank with SN1, SN2, E1, E2, or N/A (not applicable) a) Involves a carbocation intermediate: - and b) Involves retention of configuration at the site of substitution: c) Substitution at the chiral center gives predominantly a racemic product:__ d) The reaction rate can be altered by changing the concentration of the nucleophile/base: - and

Answer 1

In SN2 reaction always the nucleophile attacks from the back side of the leaving (single step reaction) and the product formation takes place through the inversion of configuration. The rate of reaction depends on the concentration of the substrate as well as on the concentration of the nucleophile.

SN2 reaction involves the formation of the carbocation intermediate (rate determining step) and the product formation takes place with racemisation. The rate of reaction depends only on the concentration of the substrae but not on the concentration of the nucleophile.

E1 reaction involves the formation of the carbocation intermediate (rate determining step).

In E2 reaction, the base abstracts proton from the alpha position of the leaving and the reaction proceeds through anti-periplanar transition state in a
1. To which mechanism(s) if any does each statement apply? Fill in each blank with SN1, SN2, E1, E2, or N/A (not applicable) a) Involves a carbocation intermediate: SN1 and E1 b) Involves retention of configuration at the site of substitution: not applicable c) Substitution at the chiral center gives predominantly a racemic product: SN1 d) The reaction rate can be altered by changing the concentration of the nucleophile/base: SN2 and E2
single step. The rate of reaction depends on the concentration of the substrate as well as on the concentration of the base..