Question

In a cohort study exploring the relationship between acute myocardial infarction and hypertension, the study investigators enrolled 10,000 people with hypertension and 10,000 people without hypertension. All study participants were healthy and had no previous history of myocardial infarction. The investigators followed the subjects until the subject developed a MI or 15 years elapsed, whichever came first. 180 of the subjects with hypertension and 30 subjects without hypertension developed MI during the course of the study. If no MI developed within 15 years, the subject was said to have no Ml. Assuming 600,000 deaths from M each year, a prevalence of hypertension of 28.6% and using the following table, how many deaths could have been averted the entire population if there were no hypertension. Disease Exposure MI No MT Hypertensive 180 9820 10,000 |Not hypertensive 3-9970 110,000 11210| 210 19,790 20,000 Total

Answer 1

AR =83.333%

AR means the strength of associations of the hypertension in developing mayocardial infraction.

Here there are 2 groups ,

A group is having 10000 candidate exposed (having hypertension)

B group is having 1000 candidate non exposed means ( not having hypertension)

In group A out of 10000 candidate having hypertension 180 developed MI

In group B out of 10,000 candidate with no hypertension only 30 develops MI.

refer paper for the calculation.
COHORT STUOY _outcorne) Ex posed Hypentens lon NonEps hon- Hyper eonsi on COHORT STUDY Non-Exposed (Nothau n) )一1 Exposed (Hawing Hypeakrsi on - HTN) o, oo Is years 18 o develbp MT) 30 (develope MI) Aributable Risk AR) ,Incidence Arnon, Exposed-Sncidence AR之 non Expose 18 o 厂80 3. 333 '1 ARS 83-333% thus 1t mecan the n MT is3.333 1 marethan the person wha do not hawe Hyper tension ?t mean the ghength ơbassocatendį Hypertension

This means their is Strong association be tuween pes tension and M.I. is very high r high means those lwhe have Hyper tensten ane likely to develop M.T. thun those who donothave ypertenin