please provide a detailed solution Which drug will be most likely absorbed through intestine (pH 7.8)...
Drug X is a weakly acidic drug that has a pKa of 7.2 a) Calculate the percentage of the ionized form of this drug in the duodenum which has a pH of 5.0? explain the concept and the scientific rationale behind your answer. b)if the pH in the stomach is 2 and that in the intestine is 8, in a new line write which of these two GIT parts drug X is maximally absorbed from; the stomach or the intestine?...
please do all parts. thank you so much
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Which drug would be most readily absorbed from the stomach (pH 2.0)? A. Weak acid, pKa 2.0 B. Weak acid, pKa 3.5 C. Weak base, pKa 3.5 D. Weak base, pKa 9.0 Fill in the ratio of ionized to non-ionized forms for a weak acid drug given the listed differences between pH and pKa: PH-pКа-2 pH-pKa-1 pH-pKa 2 PH-pka 1 pH-pKa lonized Non-ionized than its pKa - If your drug is...
please thoroughly explain
Phentolamine What is the most dominant species at pH 7.4? pka = a > H+ + НАС Verapamil pka = pKa = > H K H₃ C CH₃ → H CH,CO háchoenen OCH HCO OCH3 For each: Give the functional group name, hybridization and acidity (Acidic, Basic or Neutral) of the circled atoms •Give the likely conjugate acid form in water •Estimate the pka of circled atoms •Which one is the stronger base (blue circle) 121
25. Which of the following statements is incorrect? a. A basic solution has a pH > 7. b. An acidic solution has [H3O+]> [OH ). C. A Lewis base acts as an electron pair acceptor. d. Water acts as both a Brønsted-Lowry acid and base. e. A strong acid dissociates completely in solution. What is the pH of a buffer prepared from 0.80 M ascorbic acid, H2C6H606, and 0.50 N sodium ascorbate, NaHC6H6O6? The Ka of ascorbic acid is 6.8...
1. )An aqueous drug solution was prepared in a hospital pharmacy and the shelf-life is known to be 7 days when the solution is stored at room temperature (25oC). By using rule of thumb, estimate the shelf-life when the solution is stored at 15oC (cold room) (a) 17 days (b) 14 day (c) 5 days (d) 18 days (e) None of the above 2.) You have the assignment to prepare a water soluble injectable of atropine sulfate (pKa = 4.35)....
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Concentrations of a neutral drug in octanol and water are 1.0 mg/mL and 100 mg/ml, respectively. What is the logP value of this drug? a) -2.0 b) 0 c) 2.0 d) 4.0
Which of the following statements regarding aqueous solution pH at 25*C is correct: a) For a basic solution, pOH < 7 and [H30+] > 1x10^(-7) M b) For a basic solution, [OH-] > 1x10^(-7) M and pH > 7 c) For an acidic solution, pH < 7 and [OH-] > 1x10^(-7) M d) For an acidic solution, [H3O+] > 1x10^(-7) M and pOH < 7
33) Which of the following is most likely true of a protein that cotransports glucose and sodium ions into the intestinal cells of an animal? A) Sodium and glucose bind to the same site on the cotransporter. B) Transport of glucose against its concentration gradient provides energy for uptake of sodium ions against the electrochemical gradient. C) Sodium ions can be transported whether or not glucose is present outside the cell, but glucose transport requires cotransport of sodium ions. D)...
Which compound will most likely show an increase in solubility if you lower the pH of the solution? A) PbF2 B) NaCl C) AgCl D) CuBr E) Hg2I2 The answer is A, but can i get an explanation? And why are the others not correct
For the reaction shown in the box, which structure represents
the most likely intermediate?
Please provide explanation along with answer so I can make sure
I understand it. Thanks!
/グ \ーーーーー. + H-Br A B C D